Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.

نویسندگان

  • Jeffery J Newsome
  • Mary Hassani
  • Elizabeth Swann
  • Jane M Bibby
  • Howard D Beall
  • Christopher J Moody
چکیده

A series of heterocyclic quinones based on benzofuran, benzothiophene, indazole and benzisoxazole has been synthesized, and evaluated for their ability to function as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumor cells. Overall, the quinones are excellent substrates for NQO1, approaching the reduction rates observed for menadione.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry

دوره 21 11  شماره 

صفحات  -

تاریخ انتشار 2013